Journal article
Iron deficiency
SR Pasricha, J Tye-Din, MU Muckenthaler, DW Swinkels
Lancet | ELSEVIER SCIENCE INC | Published : 2021
Abstract
Iron deficiency is one of the leading contributors to the global burden of disease, and particularly affects children, premenopausal women, and people in low-income and middle-income countries. Anaemia is one of many consequences of iron deficiency, and clinical and functional impairments can occur in the absence of anaemia. Iron deprivation from erythroblasts and other tissues occurs when total body stores of iron are low or when inflammation causes withholding of iron from the plasma, particularly through the action of hepcidin, the main regulator of systemic iron homoeostasis. Oral iron therapy is the first line of treatment in most cases. Hepcidin upregulation by oral iron supplementatio..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
S-RP is supported by the National Health and Medical Research Council (GNT1158696) for this work, and holds grants from the National Health and Medical Research Council (GNT1159171, GNT1159151, GNT1141185, and GNT1103262) and the Bill & Melinda Gates Foundation outside the current work. JT-D is supported by a National Health and Medical Research Council Investigator Grant (GNT1176553) and the Mathison Centenary Fellowship, University of Melbourne. MUM acknowledges funding from the Deutsche Forschungsgemeinschaft (SFB1036 and SFB1118), from the Federal Ministry of Education and Research (NephrESA project Nr 031L0191C), the Dietmar Hopp-Stiftung, and the Deutscher Akademischer Austauschdienst (A New Passage to India).